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MHP - DREN
Step 1: Sympathometic thermogenic Activation:
Beta-Methoxy Phenylethlyamine (also called Beta-Methoxy PEA) is an exciting new ingredient used exclusively in DREN. Beta-Methox-PEA works in part by increasing noradrenaline (NA) release from sympathetic nerve terminals. As a sympathomimetic, Beta-Methoxy PEA acts to stimulate the sympathetic nervous system. It does this by causing pre-synaptic nerve terminals to release norepinephrine, or what is commonly called noradrenaline (NA), into the synaptic space. It also has the effect of increasing circulating adrenaline, the body’s chief beta-2 agonist. Noradrenaline, once released into the synaptic space, interacts with adrenergic receptors on the surface of adipocytes (fat). This initiates a sequence of events within the adipocyte that increases lipolysis (the breaking down of fatty acids) by the enzyme hormone sensitive lipase (HSL). This fat burning effect is dependent on long and steady activation of the receptor by the agonist and is what makes the discovery of Beta-Methoxy PEA so critical and why it is much more effective than other Beta-PEA Formulas.
Beta-Methoxy PEA is the most effective B-PEA beta-agonist by virtue of its long half-life (stays in the body longer) as well as its affinity to be absorbed in fat tissue and better permeate the blood/brain barrier. In contrast, the half-life of many other Beta-PEA forms is only minutes as the enzyme MAO-B quickly metabolizes them and are less lipophilic which prevents significant concentrations from reaching the brain--- therefore no psychoactive and weight loss effect is achieved.
Step 2: The Inclusion of an Alpha 2 Agonist works as a Clenbuterol mimetic to further Enhance Beta-Methoxy PEA fat burning!
While Beta-Methoxy-PEA by itself is a remarkably effective thermogenic, the scientists at MHP wanted to take fat burning to a new levels!
In response to Beta-Methoxy-PEA’s beta-adrenergic stimulation, negative feedback mechanisms are activated as well. This negative feedback can shutdown lipolysis (fat burning). Just the same way in which this negative feedback effect ephedra, the stimulation of the Alpha 2 receptor as well as the production of phosphodiesterases and adenosine occurs. The alpha 2 receptor, phosphodiesterases and adenosine try to slow down or halt the fat burning process which is the reason why caffeine and aspirin were often added to Ephedra products. Caffeine and aspirin overcame much of the negative feedback mechanisms and made Ephedra even better. In the case of DREN, Beta-Methoxy-PEA works in the same exact ways that Ephedra only better, but also undergoes these negative feedback mechanisms. Therefore, measures had to be taken to maximize Beta-Methoxy-PEA’s actions in the body and minimize these negative feedback mechanisms. In doing so MHP scientists were able to mimic the actions of Clenbuterol.
Ephedra and all forms of Beta-PEA are considered non-selective adrenergics through the release of noradrenaline because they don’t just active one type of receptor. Unfortunately, noradrenaline functions as its own negative feedback signal by activating both the beta and alpha adrenergic receptors.. As you recall, the stimulation of beta receptors is good as it initiates the fat burning process, but the Alpha 2 receptors actually shut down lipolysis (fat burning). MHP scientists added Yohimbine HCL to the DREN formula to by pass Alpha 2 receptor binding and increases the effectiveness of DREN. Yohimbine HCL is a selective alpha 2 antagonist and can thus short circuit this feedback loop, maximizing noradrenaline levels and the overall fat loss actions of Beta-Methoxy PEA. What we have created is a mechanism of action which closely mimics that of Clenbuterol, which is long acting activation on the beta receptor with little to no activity at the alpha receptor. Resulting in the most powerful thermogenic activity in adipose tissue possible.
Step 3: Phosphodiesterase Inhibitibiton and Adenosine Receptor Interferance
Most people like caffeine because of its stimulatory and energizing effects. But, caffeine has a much more important role than that in DREN. Stimulation of Beta-adrenergic receptor also means an increase in phosphodiesterase and adenosine activity. Phosphodiesterase (PDE) acts to hydrolyze cAMP into inactive fragments while adenosine inhibits cAMP accumulation halting the stimulation of HSL and the fat burning process. Caffeine possesses the ability to inhibit phosphodiesterases within the cell and has even been shown to have the ability to prevent some re-uptake of norepinephrine while also acting as an adenosine receptor blocker. As you can see, caffeine provides important powerful synergies to maximize DREN’s fat burning effects.
Step 4: Powerful Psycho-active “Feel Good” Neurostimulation
The mind is a powerful thing! DREN will not only transform your body with the most powerful fat burning thermogenic experience, it will also alter you mind and put you is a place you want to be “On Top of The World”. Beta-Methoxy-PEA triggers a euphoric “feel good response”. To further enhance DREN neuromudulator activity L-5-Hydroxytryptophan has also been added to the formula. L-5-Hydroxytryptophan is a naturally-occurring amino acid, a precursor to the neurotransmitter serotonin which is a monoamine neurotransmitter with feel good and appetite suppression properties. L-5-Hydroxtryptophan like Beta-Methoxy-PEA also passes through the blood brain barrier into the brain. It’s psychoactive action are thought to be derived from its effect on serotonin synthesis in central nervous system tissue. It is believed that a high supply of L-5-Hydroxytryptophan causes the brain's serotonin-producing neurons to increase production leading to increased serotonin release. The serotoninergic system is known to modulate mood, emotion, sleep and appetite and thus is implicated in the control of numerous behavioral and physiological functions. L-5-Hydroxytryptophan helps to keep serotonin and norepinephrine levels in balance therefore increasing metabolism and fat loss through synergistic actions with other ingredients in DREN. The end result is an extreme “feel good” state of euphoria.
Serving Size - 1 Capsule
Servings Per Container - 30
Amount Per Serving % Daily Value
Drenbuterol 409mg †
Mesolimbic Beta Agonist Complex
Caffeine, L-5 Hydroxytryptophan, Beta Methoxyphenylethylamine, Yohimbine HCL
† Daily Values not established
Other Ingredients
Yellow Opaque Gelatin Capsule, Maltodextrin, Silicon Dioxide, Magnesium Stearate
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