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Applied Nutriceuticals - Neovar
The Applied Nutriceuticals research and development team has developed a potent and biologically efficient post-workout nutrient enhancement product. A precisely proportioned combination of Phosphocreatine and creatine monohydrate (Mono/PCr complex) is the primary element, which plays a vital role in cellular energy production by regenerating ATP in skeletal muscle and makes it available for explosive exercises 1-5. Another important component of NeoVar, Corosolic Acid is extracted from the Banaba plant, an herb that grows in India, Southeast Asia, and the Philippines. The final component of NeoVar, D-Pinitol, is a cutting-edge compound that enhances nitric oxide production and insulin sensitivity which are key factors in nutrient transport. D-Pinitol has also been suggested to enhance intramuscular creatine deposition in human clinical studies 30. The individual effects of these compounds combine synergistically to produce a dramatic positive impact on the strength, size, and endurance of skeletal muscle tissue.
The theory behind the synergism of the Mono/PCr Complex is quite simple: It aims to match the CRfree 40/PCr 60 ratio of the naturally occurring human skeletal intramuscular creatine pool as closely as possible; allowing for greater absorption and utilization with minimal waste. The product is blended to maximize PCr levels, while at the same time including monohydrate due to its high molar percentage of creatine as the active ingredient. Human skeletal muscle creatine stores are comprised of approximately 40% in the free creatine form (CRfree), while the remaining 60% is in the phosphorylated form; creatine phosphate (CP). The Mono/PCr complex in NeoVar essentially feeds both CRfree levels and phosphocreatine levels in this optimized ratio, which is chemically identical to what is stored in the working muscles 1,3-5. Several animal studies suggest that CRfree has better availability for site phosphorylation for the production of ATP, and further studies are currently underway on the validation of this theory in humans. Similarly, research on phosphate suggests that it has numerous benefits in the athletic realm even without creatine, especially in terms of buffering lactic acid during explosive exercise. Phosphate supplementation raises levels of 2,3-diphosphoglycerate (2,3-DPG), the enzyme that unloads oxygen into muscle. Research suggests that phosphate supplementation reliably raises blood levels of 2,3-DPG, and also improves the production and use of glycogen for fuel. Therefore, this blend of both CRfree and PCr could allow skeletal muscle to "recognize" and assimilate the creatine in a more refined manner, allowing for a significant degree of uptake enhancement in skeletal muscle tissue 32-38. Additionally, the insulin mimetic compounds included in the formula may even further enhance these benefits.
A recent trend in creatine supplementation has been the development of exotic esters and alkaline/time-released delivery systems. In developing NeoVar, we researched virtually every creatine derivative currently available before arriving with the final formulation. We analyzed numerous and often conflicting studies regarding the benefits of each and found many of the so-called improvements actually reduced the effectiveness of the products they were used in. Ultimately we elected to avoid this trend, which is proving to be more about company's efforts to differentiate their products than actual effectiveness. Some of our findings include:
1. Many of the esters and delivery systems included in some of the newer products can be potentially difficult for the body to metabolize; the creatines included in NeoVar are essentially pure creatine, water, and phosphate and contain no other byproducts that could potentially hinder utilization.
2. Esters are simply fatty acid chains attached to a parent substance (in this case, creatine) that delay absorption and/or release; the newer esterified creatines actually contain less creatine, and more fatty acid chains that have no use in any type of physiological process. Several low-quality products use versions with longer esters and are only 20-30% creatine, with the rest being useless fatty acids.
3. Recent human research studies suggest that many of the alkaline creatine delivery systems actually do not work as well as creatine phosphate or creatine monohydrate as far as absorption in the digestive system and ultimately in skeletal muscle 43.
110 Capsules
Supplement Facts
Serving Size 1 Capsule
Servings Per Container 110
Amount Per Capsule 750mg
PCr-Mono Matrix™ (Proprietary Blend) 646mg
Phosphocreatine
Creatine Monohydrate
Glucovar / Adenylate Cyclase Sensitization Complex (Proprietary Blend) 104mg
Banaba Extract (Lagerstroemia Speciosa 1% Corosolic Acid) *
Gymnema Sylvestre (75% Extract0
D-Pinitol
Bioperine® (95% - 98% Piperine)* Registered Trademark Of Sabinsa Corp. And Holds Patent # 5,536,506
Inactive Ingredients
Gelatin, Candurin® Silver Fine, FD&C Red #3, FD&C Yellow #5, FD&C Blue #1
Directions: Take immediately post-workout with carbohydrates, preferably sugars. Take second dose with any other meal throughout the day containing carbohydrates.
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